PREcision Printed PERsonalized Tissue Therapies

Purpose and goal

The PREPPER project aims to develop personalized 3D-printed arterial grafts (P-3DTEA) for a first-in-man clinical trial to replace defective tissues and restore function for patients in need of arterial grafts. By developing natural and personalized grafts for implantation, we aim to address the limitations of current synthetic vascular grafts, which often suffer from poor integration, occlusions, and infections.

Expected effects and result

The PREPPER consortium aims to develop grafts that mimic native tissue, improving tissue integration while reducing complications and enhancing patient outcomes. This innovation promises higher surgical success rates, fewer complications, and new therapeutic options in vascular surgery. Personalized grafts will offer significant cost savings for payers and help to position the European bioindustry as a leader in 3D printing and advanced therapies, driving economic growth and creating new jobs.

Planned approach and implementation

PREPPER integrates precision medicine, personalization, and novel 3D printing technologies to create next-generation grafts that mimic the natural properties of arteries, enhancing durability, flexibility, and promoting tissue integration in vivo. The project will perform preclinical testing for safety and efficacy, laying the groundwork for clinical trials and European regulatory approval to set a new standard in vascular graft production and to expand regenerative medicine applications.