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Novel ultrasound-based method to predict strokes caused by atherosclerosis

Reference number
Coordinator Region Skåne - Skånes Universitetssjukhus
Funding from Vinnova SEK 3 000 000
Project duration April 2024 - March 2026
Status Ongoing
Venture Swelife - Collaboration project for better health
Call Swelife - Collaborative projects for better health autumn 2023

Purpose and goal

Ischemic stroke is often caused by the rupture of an atherosclerotic plaque in the carotid artery. Identification and treatment of patients with plaques prone to rupture is therefore an important clinical challenge today. We have recently developed a non-invasive ultrasound method (UPSA) that can assess atherosclerotic plaque composition. Our objective is to develop a "CE-marked" real-time UPSA ultrasound machine, use it for an impartial assessment in an international hospital and collect clinical in vivo data for a prospective study.

Expected effects and result

The healthcare sector is looking for a method to identify plaque composition (not just size) that is noninvasive, rapid, portable, inexpensive, and does not require contrast media or radiation. Our real-time UPSA ultrasound method meets these criteria and will be used for 1) risk stratification in healthcare, 2) screening to find individuals at risk of developing cardiovascular disease, as well as, 3) monitor interventions and to identify individuals who are suitable for inclusion in clinical trials for various interventions.

Planned approach and implementation

In collaboration between Region Skåne, Lund University, and LU Innovation in Lund, we have initiated a strategy to ensure the commercialisation and global use of our novel method. To build a scanner enabling real-time UPSA ultrasound imaging, we will establish a programming structure meeting quality management systems standards suitable for CE-marking and implement our algorithm on an OEM scanner, in consultation with experts. Subsequently, we will conduct several in vivo studies, including one at an impartial international site.

The project description has been provided by the project members themselves and the text has not been looked at by our editors.

Last updated 26 April 2024

Reference number 2023-03944