E!7335, INCANT, KAROLINSKA INSTITUTET

Purpose and goal

This project aims to develop an innovative solution for profiling therapeutic nanocarriers, including lipid nanoparticles (LNPs) and extracellular vesicles (EVs). Our goal is to create advanced hardware and software that provides precise, reliable, non-destructive characterization of nanoparticles in solution, addressing critical needs in the pharmaceutical and biotech industries. The focus is on improving the accuracy, efficiency, and throughput of LNP and EV characterization.

Expected effects and result

The proposed solution in this project has the potential to improve the profiling of Lipid Nanoparticles (LNPs) and Extracellular Vesicles (EVs), thereby accelerating the development of innovative treatments. By improving nanoparticle characterization processes, the project will facilitate advancements in gene therapy, RNA-based medicines, and vaccine development, ultimately contributing to better health outcomes and driving progress in the pharmaceutical and biotech industries.

Planned approach and implementation

The project partners will combine their key expertise to develop an innovative nanoparticle analytics solution. This will be achieved by using reference LNP and EV samples and generation of accurate datasets for LNP and EV size, concentration, polydispersity, and payload. Datasets will serve to assess system performance, to refine the system´s algorithms, and ultimately to improve the system´s precision and adaptability.