AAVNova

Important results from the project

The project aimed to conduct research for the development of a platform for bioproduction of AAV-based biological drugs, such as reagents, cells, process and analytical methods for the benefit of participating academic and industrial parties. The goal can be considered achieved since such tools, reagents, cells and processes have been established shared among the project parties. Several studies of a fundamental and applied nature have been published in leading journals and at conferences. The work has also generated new launched products in the form of new software and hardware.

Expected long term effects

The project has been successful and completed planned activities. We have established a first version of a platform for bioproduction of AAV for gene therapy. New molecular biological tools, plasmids, workflows, continuous production processes, separators, sample preparation methods and analysis software have been developed, refined and used by the project partners. Knowledge and self-confidence from the project has enabled faster product development and new product ideas within and outside the AAV area. The project has led to continued and new collaborations.

Approach and implementation

The project has been carried out within distinct work packages with several parties´ contributions within each package. Main sites of activities were located at labs in Stockholm, Tumba and Cambridge. Monthly digital update meetings as well as physical half-yearly meetings rotating between the 4 parties have contributed to successful community spirit, cross-sectoral understanding and joint problem solving. Foundational work was initially performed within each WP but was supplemented with a higher degree of intertwined implementation cross WPs in the latter part of the project.